As we know in many cultures the skull represent the dead in this case the Mexican mythology the dead was represented by Mictlantecuhtli.
According to the aztec mythology, was a god of the dead and the king of Mictlan (Chicunauhmictlan), the lowest and northernmost section of the underworld. He was one of the principal gods of the Aztecs and was the most prominent of several gods and goddesses of death and the underworld. The worship of Mictlantecuhtli sometimes involved ritual cannibalism, with human flesh being consumed in and around the temple.
Mictlantecuhtli was depicted as a blood-spattered skeleton or a person wearing a toothy skull. Although his head was typically a skull, his eye sockets did contain eyeballs. His headdress was shown decorated with owl feathers and paper banners, and he wore a necklace of human eyeballs, while his earspools were made from human bones.
He was not the only Aztec god to be depicted in this fashion, as numerous other deities had skulls for heads or else wore clothing or decorations that incorporated bones and skulls. In the Aztec world, skeletal imagery was a symbol of fertility, health and abundance, alluding to the close symbolic links between death and life. He who has gone, so we but cherish his memory, abides with us, more potent, and more present than the living man. Source: Wikipedia


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